Cargando…

Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis

BACKGROUND: Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult patients. Elucidating novel transcriptomic and epigenetic contributors to the molecular heterogeneity underlying its aggressiveness may lead to improved clinical outcomes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Chang, Song, Xiao, Zhang, Zhou, Cai, Qinyun, Cai, Jiajun, Horbinski, Craig, Hu, Bo, Cheng, Shi-Yuan, Zhang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426201/ https://www.ncbi.nlm.nih.gov/pubmed/37580817 http://dx.doi.org/10.1186/s40478-023-01619-5

Ejemplares similares

RUNX1 and REXO2 are associated with the heterogeneity and prognosis of IDH wild type lower grade glioma
por: Wang, Haiwei, et al.
Publicado: (2021)

Identification of an epigenetic prognostic signature for patients with lower‐grade gliomas
por: Yu, Hai, et al.
Publicado: (2021)

Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications
por: Comba, Andrea, et al.
Publicado: (2021)

Comprehensive Characterization of Pyroptosis Patterns with Implications in Prognosis and Immunotherapy in Low-Grade Gliomas
por: Zhou, Zijian, et al.
Publicado: (2022)

Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma
por: Shi, Bo, et al.
Publicado: (2023)

Systematic transcriptome profiling of pyroptosis related signature for predicting prognosis and immune landscape in lower grade glioma
por: Yu, Huihan, et al.
Publicado: (2022)

Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas
por: Li, Ming-Yang, et al.
Publicado: (2015)

Heterogeneity in clinical prognosis, immune infiltration and molecular characteristics of three glycolytic subtypes in lower-grade gliomas
por: Wu, Shenglian, et al.
Publicado: (2023)

Implications of CRNDE in prognosis, tumor immunity, and therapeutic sensitivity in low grade glioma patients
por: Yang, Chen, et al.
Publicado: (2023)

Genome‐wide methylomic analyses identify prognostic epigenetic signature in lower grade glioma
por: Guo, Wenna, et al.
Publicado: (2021)

Characterization of aging cancer-associated fibroblasts draws implications in prognosis and immunotherapy response in low-grade gliomas
por: Zhou, Zijian, et al.
Publicado: (2022)

Patient-derived xenografts of different grade gliomas retain the heterogeneous histological and genetic features of human gliomas
por: Zeng, Wenxin, et al.
Publicado: (2020)

Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
por: Hua, Xing, et al.
Publicado: (2020)

Epigenetically regulated lncRNAs dissect the intratumoural heterogeneity and facilitate immune evasion of glioblastomas
por: Xu, Dahua, et al.
Publicado: (2023)

LGG-58. Understanding the transcriptional heterogeneity of pediatric low-grade gliomas and its implication for tumor pathophysiology
por: Boisvert, Michelle, et al.
Publicado: (2022)

An Immune-Related Signature for Predicting the Prognosis of Lower-Grade Gliomas
por: Zhang, Hongbo, et al.
Publicado: (2020)

Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma
por: Bugiani, Marianna, et al.
Publicado: (2017)

Dissecting and analyzing the Subclonal Mutations Associated with Poor Prognosis in Diffuse Glioma
por: Bai, Ming, et al.
Publicado: (2022)

Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas
por: Salloum, Ralph, et al.
Publicado: (2017)

Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas
por: Lazow, Margot A., et al.
Publicado: (2020)

Association of RNA-modification “writer” genes with prognosis and response to immunotherapy in patients with low-grade glioma
por: Zhang, Lupeng, et al.
Publicado: (2023)

Prognosis and immunoinfiltration analysis of angiogene-related genes in grade 4 diffuse gliomas
por: Liu, Hui, et al.
Publicado: (2023)

Dissecting pulmonary fibroblasts heterogeneity in lung development, health and diseases
por: Zhang, Xinxin, et al.
Publicado: (2023)

Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma
por: Li, Yong, et al.
Publicado: (2020)

Transcriptomic Characterization of Copper-Binding Proteins for Predicting Prognosis in Glioma
por: Zeng, Hao-Long, et al.
Publicado: (2023)

Characterization of aging tumor microenvironment with drawing implications in predicting the prognosis and immunotherapy response in low-grade gliomas
por: Zhou, Zijian, et al.
Publicado: (2022)

MGME1 associates with poor prognosis and is vital for cell proliferation in lower-grade glioma
por: Xiao, Feng, et al.
Publicado: (2023)

Immunogenic cell death-related risk signature predicts prognosis and characterizes the tumour microenvironment in lower-grade glioma
por: Cai, Jiayang, et al.
Publicado: (2022)

Systematic Analysis of a Pyroptosis-Related Signature to Predict the Prognosis and Immune Microenvironment of Lower-Grade Glioma
por: He, Yongze, et al.
Publicado: (2022)

A GLO10 score for the prediction of prognosis in high grade gliomas
por: Chen, Feng, et al.
Publicado: (2017)

IDH1 mutant glioma is preferentially sensitive to the HDAC inhibitor panobinostat
por: Sears, Thomas K., et al.
Publicado: (2021)

Mycobacterium tuberculosis complex molecular networks and their regulation: Implications of strain heterogeneity on epigenetic diversity and transcriptome regulation
por: Mvubu, Nontobeko Eunice, et al.
Publicado: (2023)

Subtype and grade-dependent spatial heterogeneity of T-cell infiltration in pediatric glioma
por: Robinson, M Hope, et al.
Publicado: (2020)

Heterogeneous Expression of Proangiogenic and Coagulation Proteins in Gliomas of Different Histopathological Grade
por: Wojtukiewicz, Marek Z., et al.
Publicado: (2021)

EpiDISH web server: Epigenetic Dissection of Intra-Sample-Heterogeneity with online GUI
por: Zheng, Shijie C, et al.
Publicado: (2020)

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics
por: Hoffman, Lindsey M., et al.
Publicado: (2016)

Low-Dose Apatinib Improves the Prognosis of Patients with Recurrent High-Grade Gliomas
por: Zhang, Ming, et al.
Publicado: (2022)

Transcriptional Characteristics of IDH-Wild Type Glioma Subgroups Highlight the Biological Processes Underlying Heterogeneity of IDH-Wild Type WHO Grade IV Gliomas
por: Chang, Yu-Zhou, et al.
Publicado: (2020)

Pathological Grade-Associated Transcriptome Profiling of lncRNAs and mRNAs in Gliomas
por: Sun, Junlong, et al.
Publicado: (2020)

Hypomethylation of CNTFRα is associated with proliferation and poor prognosis in lower grade gliomas
por: Fan, Kun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6hi6nnp56sedhqgk4fafr6n98t