Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria

BACKGROUND: Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control. One such gene drive involves the dsxF(CRISPRh) transgene encoding (i) hCas9 endonuclease, (ii) T1 guide RNA (gRNA) targeting the doublesex locus,...

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Detalles Bibliográficos
Autores principales: Qureshi, Alima, Connolly, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426224/
https://www.ncbi.nlm.nih.gov/pubmed/37580703
http://dx.doi.org/10.1186/s12936-023-04665-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426224/
https://www.ncbi.nlm.nih.gov/pubmed/37580703
http://dx.doi.org/10.1186/s12936-023-04665-5

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