Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

Hepatitis B virus (HBV) infection kinetics in immunodeficient mice reconstituted with humanized livers from inoculation to steady state is highly dynamic despite the absence of an adaptive immune response. To recapitulate the multiphasic viral kinetic patterns, we developed an agent-based model that...

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Detalles Bibliográficos
Autores principales: Hailegiorgis, Atesmachew, Ishida, Yuji, Collier, Nicholson, Imamura, Michio, Shi, Zhenzhen, Reinharz, Vladimir, Tsuge, Masataka, Barash, Danny, Hiraga, Nobuhiko, Yokomichi, Hiroshi, Tateno, Chise, Ozik, Jonathan, Uprichard, Susan L., Chayama, Kazuaki, Dahari, Harel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426918/
https://www.ncbi.nlm.nih.gov/pubmed/37535676
http://dx.doi.org/10.1371/journal.pcbi.1011309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426918/
https://www.ncbi.nlm.nih.gov/pubmed/37535676
http://dx.doi.org/10.1371/journal.pcbi.1011309

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