Cargando…

Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

Hepatitis B virus (HBV) infection kinetics in immunodeficient mice reconstituted with humanized livers from inoculation to steady state is highly dynamic despite the absence of an adaptive immune response. To recapitulate the multiphasic viral kinetic patterns, we developed an agent-based model that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hailegiorgis, Atesmachew, Ishida, Yuji, Collier, Nicholson, Imamura, Michio, Shi, Zhenzhen, Reinharz, Vladimir, Tsuge, Masataka, Barash, Danny, Hiraga, Nobuhiko, Yokomichi, Hiroshi, Tateno, Chise, Ozik, Jonathan, Uprichard, Susan L., Chayama, Kazuaki, Dahari, Harel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426918/ https://www.ncbi.nlm.nih.gov/pubmed/37535676 http://dx.doi.org/10.1371/journal.pcbi.1011309

Ejemplares similares

Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection
por: Tsuge, Masataka, et al.
Publicado: (2019)

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus
por: Miyaki, Eisuke, et al.
Publicado: (2017)

HCV kinetic and modeling analyses project shorter durations to cure under combined therapy with daclatasvir and asunaprevir in chronic HCV-infected patients
por: Canini, Laetitia, et al.
Publicado: (2017)

Agent-Based Model Forecasts Aging of the Population of People Who Inject Drugs in Metropolitan Chicago and Changing Prevalence of Hepatitis C Infections
por: Gutfraind, Alexander, et al.
Publicado: (2015)

A Robust and Efficient Numerical Method for RNA-Mediated Viral Dynamics
por: Reinharz, Vladimir, et al.
Publicado: (2017)

Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP
por: Makokha, Grace Naswa, et al.
Publicado: (2019)

Publisher Correction: Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP
por: Makokha, Grace Naswa, et al.
Publicado: (2020)

Efficient Methods for Parameter Estimation of Ordinary and Partial Differential Equation Models of Viral Hepatitis Kinetics
por: Churkin, Alexander, et al.
Publicado: (2020)

Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor
por: Sainz, Bruno, et al.
Publicado: (2012)

Hepatitis C Virus Infection Suppresses the Interferon Response in the Liver of the Human Hepatocyte Chimeric Mouse
por: Tsuge, Masataka, et al.
Publicado: (2011)

Hepatitis B Virus-Specific miRNAs and Argonaute2 Play a Role in the Viral Life Cycle
por: Hayes, C. Nelson, et al.
Publicado: (2012)

Modeling hepatitis C micro-elimination among people who inject drugs with direct-acting antivirals in metropolitan Chicago
por: Tatara, Eric, et al.
Publicado: (2022)

Spatial inequities in access to medications for treatment of opioid use disorder highlight scarcity of methadone providers under counterfactual scenarios
por: Tatara, Eric, et al.
Publicado: (2023)

Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection
por: Ohya, Kazuki, et al.
Publicado: (2019)

Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs
por: Yamasaki, Chihiro, et al.
Publicado: (2020)

Liver fibrosis assessments using FibroScan, virtual-touch tissue quantification, the FIB-4 index, and mac-2 binding protein glycosylation isomer levels compared with pathological findings of liver resection specimens in patients with hepatitis C infection
por: Ueda, Naoyuki, et al.
Publicado: (2020)

Accounting for Space — Quantification of Cell-To-Cell Transmission Kinetics Using Virus Dynamics Models
por: Kumberger, Peter, et al.
Publicado: (2018)

Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers
por: Ishida, Yuji, et al.
Publicado: (2020)

People who inject drugs in metropolitan Chicago: A meta-analysis of data from 1997-2017 to inform interventions and computational modeling toward hepatitis C microelimination
por: Boodram, Basmattee, et al.
Publicado: (2022)

Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay
por: Yoshimi, Satoshi, et al.
Publicado: (2015)

Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy
por: Ono, Atsushi, et al.
Publicado: (2015)

Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies
por: Malespin, Miguel, et al.
Publicado: (2016)

HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study
por: Miki, Daiki, et al.
Publicado: (2013)

Early experience of seven hepatocellular carcinoma cases treated with regorafenib
por: Uchikawa, Shinsuke, et al.
Publicado: (2018)

Early changes in ammonia levels and liver function in patients with advanced hepatocellular carcinoma treated by lenvatinib therapy
por: Ohya, Kazuki, et al.
Publicado: (2019)

Learning-accelerated discovery of immune-tumour interactions
por: Ozik, Jonathan, et al.
Publicado: (2019)

Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis
por: Fujino, Hatsue, et al.
Publicado: (2019)

Sequentially calibrating a Bayesian microsimulation model to incorporate new information and assumptions
por: DeYoreo, Maria, et al.
Publicado: (2022)

HCV Spread Kinetics Reveal Varying Contributions of Transmission Modes to Infection Dynamics
por: Durso-Cain, Karina, et al.
Publicado: (2021)

Retrospective Identification of Herpes Simplex 2 Virus-Associated Acute Liver Failure in an Immunocompetent Patient Detected Using Whole Transcriptome Shotgun Sequencing
por: Ono, Atsushi, et al.
Publicado: (2017)

In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism
por: Liu, Songyao, et al.
Publicado: (2021)

Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib
por: Fujii, Yasutoshi, et al.
Publicado: (2021)

Modeling-Based Response-Guided DAA Therapy for Chronic Hepatitis C to Identify Individuals for Shortening Treatment Duration
por: Goyal, Ashish, et al.
Publicado: (2022)

Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring
por: Honda, Fumi, et al.
Publicado: (2018)

TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
por: Aizawa, Sayaka, et al.
Publicado: (2016)

Characterization and Valuation of the Uncertainty of Calibrated Parameters in Microsimulation Decision Models
por: Alarid-Escudero, Fernando, et al.
Publicado: (2022)

Robustness Analysis of Colorectal Cancer Colonoscopy Screening Strategies
por: de Lima, Pedro Nascimento, et al.
Publicado: (2023)

A Human Hepatocyte-Bearing Mouse: An Animal Model to Predict Drug Metabolism and Effectiveness in Humans
por: Yoshizato, Katsutoshi, et al.
Publicado: (2009)

Characterization and applications of chimeric mice with humanized livers for preclinical drug development
por: Tateno, Chise, et al.
Publicado: (2020)

Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib
por: Ono, Atsushi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2ojtvt76p6qtnp4k14slrhoirb