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How ligands regulate the binding of PARP1 with DNA: Deciphering the mechanism at the molecular level
The catalytic (CAT) domain is a key region of poly (ADP-ribose) polymerase 1 (PARP1), which has crucial interactions with inhibitors, DNA, and other domains of PARP1. To facilitate the development of potential inhibitors of PARP1, it is of great significance to clarify the differences in structural...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426920/ https://www.ncbi.nlm.nih.gov/pubmed/37582112 http://dx.doi.org/10.1371/journal.pone.0290176 |