Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype

New variants of SARS-CoV-2 are continually emerging with mutations in spike associated with increased transmissibility and immune escape. Phenotypic maps can inform the prediction of concerning mutations from genomic surveillance, however most of these maps currently derive from studies using monome...

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Detalles Bibliográficos
Autores principales: Kugathasan, Ruthiran, Sukhova, Ksenia, Moshe, Maya, Kellam, Paul, Barclay, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426949/
https://www.ncbi.nlm.nih.gov/pubmed/37535672
http://dx.doi.org/10.1371/journal.ppat.1011545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426949/
https://www.ncbi.nlm.nih.gov/pubmed/37535672
http://dx.doi.org/10.1371/journal.ppat.1011545

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