FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo

Functional analyses of genes linked to heritable forms of Parkinson’s disease (PD) have revealed fundamental insights into the biological processes underpinning pathogenic mechanisms. Mutations in PARK15/FBXO7 cause autosomal recessive PD and FBXO7 has been shown to regulate mitochondrial homeostasi...

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Detalles Bibliográficos
Autores principales: Sanchez-Martinez, Alvaro, Martinez, Aitor, Whitworth, Alexander J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427020/
https://www.ncbi.nlm.nih.gov/pubmed/37535686
http://dx.doi.org/10.1371/journal.pbio.3002244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427020/
https://www.ncbi.nlm.nih.gov/pubmed/37535686
http://dx.doi.org/10.1371/journal.pbio.3002244

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