Thermoresponsive Polypeptide Fused L‐Asparaginase with Mitigated Immunogenicity and Enhanced Efficacy in Treating Hematologic Malignancies

L‐Asparaginase (ASP) is well‐known for its excellent efficacy in treating hematological malignancies. Unfortunately, the intrinsic shortcomings of ASP, namely high immunogenicity, severe toxicity, short half‐life, and poor stability, restrict its clinical usage. Poly(ethylene glycol) conjugation (PE...

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Detalles Bibliográficos
Autores principales: Zhang, Sanke, Sun, Yuanzi, Zhang, Longshuai, Zhang, Fan, Gao, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427413/
https://www.ncbi.nlm.nih.gov/pubmed/37271878
http://dx.doi.org/10.1002/advs.202300469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427413/
https://www.ncbi.nlm.nih.gov/pubmed/37271878
http://dx.doi.org/10.1002/advs.202300469

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