Cargando…

Thermoresponsive Polypeptide Fused L‐Asparaginase with Mitigated Immunogenicity and Enhanced Efficacy in Treating Hematologic Malignancies

L‐Asparaginase (ASP) is well‐known for its excellent efficacy in treating hematological malignancies. Unfortunately, the intrinsic shortcomings of ASP, namely high immunogenicity, severe toxicity, short half‐life, and poor stability, restrict its clinical usage. Poly(ethylene glycol) conjugation (PE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Sanke, Sun, Yuanzi, Zhang, Longshuai, Zhang, Fan, Gao, Weiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427413/ https://www.ncbi.nlm.nih.gov/pubmed/37271878 http://dx.doi.org/10.1002/advs.202300469

Ejemplares similares

Immunogenic Cell Death in Hematological Malignancy Therapy
por: Liu, Zhaoyun, et al.
Publicado: (2023)

Thermoresponsive and Protease‐Cleavable Interferon‐Polypeptide Conjugates with Spatiotemporally Programmed Two‐Step Release Kinetics for Tumor Therapy
por: Wang, Zhuoran, et al.
Publicado: (2019)

Bifunctional fused polypeptide inhibits the growth and metastasis of breast cancer
por: Liang, Ai-Ling, et al.
Publicado: (2015)

Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginases
por: Pokrovsky, Vadim S., et al.
Publicado: (2016)

Physicochemical Characterization of a Biomimetic, Elastin-Inspired Polypeptide with Enhanced Thermoresponsive Properties and Improved Cell Adhesion
por: Bandiera, Antonella, et al.
Publicado: (2023)

Thermoresponsive Gels
por: Taylor, M. Joan, et al.
Publicado: (2017)

Thermoresponsive Polypeptoids
por: Liu, Dandan, et al.
Publicado: (2020)

ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XV. STUDIES ON THE IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE
por: Pinchuck, Paul, et al.
Publicado: (1965)

Characterization of a Novel L-Asparaginase from Mycobacterium gordonae with Acrylamide Mitigation Potential
por: Chi, Huibing, et al.
Publicado: (2021)

Weak immunogenicity of SARS-CoV-2 vaccine in patients with hematologic malignancies
por: Malard, Florent, et al.
Publicado: (2021)

ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS) : XVI. GENETIC CONTROL OF IMMUNOGENICITY OF SYNTHETIC POLYPEPTIDES IN MICE
por: Pinchuck, Paul, et al.
Publicado: (1965)

Peptide/protein-based macrocycles: from biological synthesis to biomedical applications
por: Wu, Wen-Hao, et al.
Publicado: (2022)

P1557: A STUDY ON THE IMMUNOGENICITY OF COVID-19 VACCINE IN PATIENTS WITH HEMATOLOGIC MALIGNANCY
por: Mesina, Flordeluna, et al.
Publicado: (2023)

Potential Immunogenic Polypeptides of Burkholderia pseudomallei Identified by Shotgun Expression Library and Evaluation of Their Efficacy for Serodiagnosis of Melioidosis
por: Puah, Suat Moi, et al.
Publicado: (2013)

Increased Immunogenicity and Protective Efficacy of Influenza M2e Fused to a Tetramerizing Protein
por: Andersson, Anne-Marie Carola, et al.
Publicado: (2012)

Autophagy protects against human islet amyloid polypeptide‐associated apoptosis
por: Morita, Shuhei, et al.
Publicado: (2011)

Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115
por: El-Naggar, Noura El-Ahmady, et al.
Publicado: (2018)

Identification of L-asparaginases from Streptomyces strains with competitive activity and immunogenic profiles: a bioinformatic approach
por: González-Torres, Iván, et al.
Publicado: (2020)

Incidence and risk of falls in patients treated for hematologic malignancies in the Intensive Hematology Unit
por: Lorca, Luz Alejandra, et al.
Publicado: (2019)

Efficacy and safety of endoscopic retrograde cholangiopancreatography in recurrent pancreatitis of pediatric asparaginase-associated pancreatitis
por: Yang, Kai-Hua, et al.
Publicado: (2023)

Microbial L-asparaginase for Application in Acrylamide Mitigation from Food: Current Research Status and Future Perspectives
por: Jia, Ruiying, et al.
Publicado: (2021)

Efficacy and safety of PEG-asparaginase versus E. coli L-asparaginase in Chinese children with acute lymphoblastic leukemia: a meta-analysis
por: Dai, Zhan-Jing, et al.
Publicado: (2021)

Photomotion of Hydrogels with Covalently Attached Azo Dye Moieties—Thermoresponsive and Non-Thermoresponsive Gels
por: Jaik, Thorben G., et al.
Publicado: (2022)

Immunogenicity of COVID-19 vaccines in patients with hematologic malignancies: a systematic review and meta-analysis
por: Teh, Joanne S. K., et al.
Publicado: (2022)

Effectiveness, immunogenicity, and safety of COVID-19 vaccines for individuals with hematological malignancies: a systematic review
por: Piechotta, Vanessa, et al.
Publicado: (2022)

Low Bioavailability and High Immunogenicity of a New Brand of E. colil-Asparaginase with Active Host Contaminating Proteins
por: Zenatti, Priscila Pini, et al.
Publicado: (2018)

Antiproliferative effects of L-asparaginase in acute myeloid leukemia
por: Chen, Tingting, et al.
Publicado: (2020)

Instantaneous Degelling Thermoresponsive Hydrogel
por: Steinman, Noam Y., et al.
Publicado: (2021)

Mitigation of acrylamide by l-asparaginase from Bacillus subtilis KDPS1 and analysis of degradation products by HPLC and HPTLC
por: Sanghvi, Gaurav, et al.
Publicado: (2016)

Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase
por: Hlozkova, Katerina, et al.
Publicado: (2020)

Thermoresponsive Polymers of Poly(2-(N-alkylacrylamide)ethyl acetate)s
por: Liu, Xue, et al.
Publicado: (2020)

SARS-CoV-2 vaccine safety and immunogenicity in patients with hematologic malignancies, transplantation, and cellular therapies
por: Ni, Bin, et al.
Publicado: (2022)

Immunogenicity of the ChAdOx1 nCoV-19 vaccine in patients with hematologic malignancies
por: Thookhamme, Chayapa, et al.
Publicado: (2023)

Ferroptosis in hematological malignant tumors
por: Liu, Yong, et al.
Publicado: (2023)

Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants()
por: Gómez, N., et al.
Publicado: (1998)

Role of Fused Mycobacterium tuberculosis Immunogens and Adjuvants in Modern Tuberculosis Vaccines
por: Junqueira-Kipnis, Ana Paula, et al.
Publicado: (2014)

Accuracy of diagnosis and individualization of treatment: the way of treating hematologic malignancies
por: Liu, Dai-Hong
Publicado: (2020)

Alternative splicing of BCL-X and implications for treating hematological malignancies
por: Chen, Wanling, et al.
Publicado: (2021)

Development and application of nanomaterials, nanotechnology and nanomedicine for treating hematological malignancies
por: Li, Jinxin, et al.
Publicado: (2023)

Protective role of human insulin against the cytotoxicity associated with human mutant S20G islet amyloid polypeptide
por: Morita, Shuhei, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_h0tbhlfcknu6lgvimkl14uf8pi