Cargando…

NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis

Cell fate and proliferation ability can be transformed through reprogramming technology. Reprogramming glioblastoma cells into neuron-like cells holds great promise for glioblastoma treatment, as it induces their terminal differentiation. NeuroD4 (Neuronal Differentiation 4) is a crucial transcripti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hao, Zhao, Peiqi, Zhang, Ying, Chen, Zhen, Bao, Han, Qian, Wenqi, Wu, Jian, Xing, Zhenqiu, Hu, Xiaowei, Jin, Kunlin, Zhuge, Qichuan, Yang, Jianjing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427652/ https://www.ncbi.nlm.nih.gov/pubmed/37582760 http://dx.doi.org/10.1038/s41420-023-01595-8

Ejemplares similares

Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axis
por: Yan, Xiangying, et al.
Publicado: (2023)

NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma
por: Cheng, Yan, et al.
Publicado: (2020)

Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway
por: Wang, Xingjie, et al.
Publicado: (2023)

Failure of observing NeuroD1-induced microglia-to-neuron conversion in vitro is not attributed to the low NeuroD1 expression level
por: Rao, Yanxia, et al.
Publicado: (2022)

PTBP1 knockdown promotes neural differentiation of glioblastoma cells through UNC5B receptor
por: Wang, Kankai, et al.
Publicado: (2022)

Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury
por: Fukuoka, Toshiki, et al.
Publicado: (2021)

NeuroD1 promotes neuroblastoma cell growth by inducing the expression of ALK
por: Lu, Fangjin, et al.
Publicado: (2015)

Hes6 Is Required for the Neurogenic Activity of Neurogenin and NeuroD
por: Murai, Kasumi, et al.
Publicado: (2011)

Mechanistic Insights in NeuroD Potentiation of Mineralocorticoid Receptor Signaling
por: van Weert, Lisa T. C. M., et al.
Publicado: (2019)

Involvement of FSP1-CoQ(10)-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
por: Yang, Ming, et al.
Publicado: (2022)

Overexpressing NeuroD1 reprograms Müller cells into various types of retinal neurons
por: Xu, Di, et al.
Publicado: (2022)

GBE1 Promotes Glioma Progression by Enhancing Aerobic Glycolysis through Inhibition of FBP1
por: Chen, Zhen, et al.
Publicado: (2023)

Lipid Peroxides Mediated Ferroptosis in Electromagnetic Pulse-Induced Hippocampal Neuronal Damage via Inhibition of GSH/GPX4 Axis
por: Lai, Yunfei, et al.
Publicado: (2022)

System X(c) (−)/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
por: Li, Feng-Jiao, et al.
Publicado: (2022)

NeuroD2 regulates the development of hippocampal mossy fiber synapses
por: Wilke, Scott A, et al.
Publicado: (2012)

Transcriptomic analyses of NeuroD1‐mediated astrocyte‐to‐neuron conversion
por: Ma, Ning‐Xin, et al.
Publicado: (2022)

Interleukin-4 Ameliorates the Functional Recovery of Intracerebral Hemorrhage Through the Alternative Activation of Microglia/Macrophage
por: Yang, Jianjing, et al.
Publicado: (2016)

NeuroD2 controls inhibitory circuit formation in the molecular layer of the cerebellum
por: Pieper, Alexander, et al.
Publicado: (2019)

MYCN Directly Targets NeuroD1 to Promote Cellular Proliferation in Neuroblastoma
por: Lu, Fangjin, et al.
Publicado: (2022)

NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
por: Konrad, Kalin D., et al.
Publicado: (2022)

The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors
por: Zhao, Liqun, et al.
Publicado: (2023)

Neuroprotective effect of Dl-3-n-butylphthalide against ischemia–reperfusion injury is mediated by ferroptosis regulation via the SLC7A11/GSH/GPX4 pathway and the attenuation of blood–brain barrier disruption
por: Xu, Shuangli, et al.
Publicado: (2023)

GPX4 in cell death, autophagy, and disease
por: Xie, Yangchun, et al.
Publicado: (2023)

Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging
por: Coder, Brandon, et al.
Publicado: (2016)

Deregulation of CREB Signaling Pathway Induced by Chronic Hyperglycemia Downregulates NeuroD Transcription
por: Cho, In-Su, et al.
Publicado: (2012)

Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos
por: Kumar, Ajeet, et al.
Publicado: (2017)

The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement
por: Bimpisidis, Zisis, et al.
Publicado: (2019)

ERK Regulates NeuroD1-mediated Neurite Outgrowth via Proteasomal Degradation
por: Lee, Tae-young, et al.
Publicado: (2020)

Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells
por: Ferrucci, Michela, et al.
Publicado: (2017)

Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts
por: Wang, Mengyi, et al.
Publicado: (2023)

Capsaicin induces ferroptosis of NSCLC by regulating SLC7A11/GPX4 signaling in vitro
por: Liu, Xiao-Yan, et al.
Publicado: (2022)

Multi-site phosphorylation regulates NeuroD4 activity during primary neurogenesis: a conserved mechanism amongst proneural proteins
por: Hardwick, Laura J. A., et al.
Publicado: (2015)

A Reliable Nonhuman Primate Model of Ischemic Stroke with Reproducible Infarct Size and Long-term Sensorimotor Deficits
por: Lin, Xiao, et al.
Publicado: (2023)

Promoter-Specific Variants in NeuroD1 and H3K4me3 Coincident Regions and Clinical Outcomes of Small Cell Lung Cancer
por: Yoo, Seung Soo, et al.
Publicado: (2023)

Tcf12 and NeuroD1 cooperatively drive neuronal migration during cortical development
por: Singh, Aditi, et al.
Publicado: (2022)

Translational Regulation of GPx-1 and GPx-4 by the mTOR Pathway
por: Reinke, Emily N., et al.
Publicado: (2014)

Generation of Insulin-Expressing Cells in Mouse Small Intestine by Pdx1, MafA, and BETA2/NeuroD
por: Lee, So-Hyun, et al.
Publicado: (2017)

Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types
por: Matsuda-Ito, Kanae, et al.
Publicado: (2022)

SLC7A11/GPX4 Inactivation-Mediated Ferroptosis Contributes to the Pathogenesis of Triptolide-Induced Cardiotoxicity
por: Liu, Xian, et al.
Publicado: (2022)

TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells
por: Kim, Do Hyung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7m4lmqvh6eeebmtipgvt5brfjk