CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties

Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism is a necessary initiating oncogenic event during tumorigenesis of esophageal squamous cell carcinoma (ESCC). We discover that cyclin-dependent kinase...

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Detalles Bibliográficos
Autores principales: Lv, Mengzhu, Gong, Ying, Liu, Xuesong, Wang, Yan, Wu, Qingnan, Chen, Jie, Min, Qingjie, Zhao, Dongyu, Li, Xianfeng, Chen, Dongshao, Yang, Di, Yeerken, Danna, Liu, Rui, Li, Jinting, Zhang, Weimin, Zhan, Qimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427695/
https://www.ncbi.nlm.nih.gov/pubmed/37582812
http://dx.doi.org/10.1038/s41392-023-01555-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427695/
https://www.ncbi.nlm.nih.gov/pubmed/37582812
http://dx.doi.org/10.1038/s41392-023-01555-9

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