Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes

INTRODUCTION: In spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the insulin B chain peptide 9-23 (B:9-23) can bind to the MHC class II molecule (IA(g7)) in register 3 (R3), creating a bimolecular IA(g7)/InsulinB:9-23 register 3 conformational epitope (InsB:R3). Previously, we showe...

Description complète

Détails bibliographiques
Auteurs principaux: Obarorakpor, Nyerhovwo, Patel, Deep, Boyarov, Reni, Amarsaikhan, Nansalmaa, Cepeda, Joseph Ray, Eastes, Doreen, Robertson, Sylvia, Johnson, Travis, Yang, Kai, Tang, Qizhi, Zhang, Li
Format: Online Article Texte
Langue:English
Publié: Frontiers Media S.A. 2023
Sujets:
Immunology
Accès en ligne:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428008/
https://www.ncbi.nlm.nih.gov/pubmed/37593744
http://dx.doi.org/10.3389/fimmu.2023.1207108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428008/
https://www.ncbi.nlm.nih.gov/pubmed/37593744
http://dx.doi.org/10.3389/fimmu.2023.1207108

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