The NRF2-p97-NRF2 negative feedback loop

p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating pr...

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Detalles Bibliográficos
Autores principales: Shakya, Aryatara, Liu, Pengfei, Godek, Jack, McKee, Nicholas W., Dodson, Matthew, Anandhan, Annadurai, Ooi, Aikseng, Garcia, Joe G.N., Costa, Max, Chapman, Eli, Zhang, Donna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428046/
https://www.ncbi.nlm.nih.gov/pubmed/37573837
http://dx.doi.org/10.1016/j.redox.2023.102839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428046/
https://www.ncbi.nlm.nih.gov/pubmed/37573837
http://dx.doi.org/10.1016/j.redox.2023.102839

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