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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies. Using a murine AML model, human AML cell lines, and patient samples, we show that AML LICs are sensitive to endoge...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428076/ https://www.ncbi.nlm.nih.gov/pubmed/37459233 http://dx.doi.org/10.1016/j.celrep.2023.112794 |