Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies. Using a murine AML model, human AML cell lines, and patient samples, we show that AML LICs are sensitive to endoge...

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Detalles Bibliográficos
Autores principales: Qian, Fenghua, Nettleford, Shaneice K., Zhou, Jiayan, Arner, Brooke E., Hall, Molly A., Sharma, Arati, Annageldiyev, Charyguly, Rossi, Randy M., Tukaramrao, Diwakar B., Sarkar, Deborpita, Hegde, Shailaja, Gandhi, Ujjawal H., Finch, Emily R., Goodfield, Laura, Quickel, Michael D., Claxton, David F., Paulson, Robert F., Prabhu, K. Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428076/
https://www.ncbi.nlm.nih.gov/pubmed/37459233
http://dx.doi.org/10.1016/j.celrep.2023.112794

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