Kinetic Barrier to Enzyme Inhibition Is Manipulated by Dynamical Local Interactions in E. coli DHFR

[Image: see text] Dihydrofolate reductase (DHFR) is an important drug target and a highly studied model protein for understanding enzyme dynamics. DHFR’s crucial role in folate synthesis renders it an ideal candidate to understand protein function and protein evolution mechanisms. In this study, to...

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Detalles Bibliográficos
Autores principales: Cetin, Ebru, Guclu, Tandac F., Kantarcioglu, Isik, Gaszek, Ilona K., Toprak, Erdal, Atilgan, Ali Rana, Dedeoglu, Burcu, Atilgan, Canan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428214/
https://www.ncbi.nlm.nih.gov/pubmed/37491825
http://dx.doi.org/10.1021/acs.jcim.3c00818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428214/
https://www.ncbi.nlm.nih.gov/pubmed/37491825
http://dx.doi.org/10.1021/acs.jcim.3c00818

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