Molecular Dynamics and Machine Learning Give Insights on the Flexibility–Activity Relationships in Tyrosine Kinome

[Image: see text] Tyrosine kinases are a subfamily of kinases with critical roles in cellular machinery. Dysregulation of their active or inactive forms is associated with diseases like cancer. This study aimed to holistically understand their flexibility–activity relationships, focusing on pockets...

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Detalles Bibliográficos
Autores principales: Majumdar, Sarmistha, Di Palma, Francesco, Spyrakis, Francesca, Decherchi, Sergio, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428216/
https://www.ncbi.nlm.nih.gov/pubmed/37462363
http://dx.doi.org/10.1021/acs.jcim.3c00738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428216/
https://www.ncbi.nlm.nih.gov/pubmed/37462363
http://dx.doi.org/10.1021/acs.jcim.3c00738

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