Integrated Approach Including Docking, MD Simulations, and Network Analysis Highlights the Action Mechanism of the Cardiac hERG Activator RPR260243

[Image: see text] hERG is a voltage-gated potassium channel involved in the heart contraction whose defections are associated with the cardiac arrhythmia Long QT Syndrome type 2. The activator RPR260243 (RPR) represents a possible candidate to pharmacologically treat LQTS2 because it enhances the op...

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Detalles Bibliográficos
Autores principales: Costa, Flavio, Ocello, Riccardo, Guardiani, Carlo, Giacomello, Alberto, Masetti, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428221/
https://www.ncbi.nlm.nih.gov/pubmed/37504578
http://dx.doi.org/10.1021/acs.jcim.3c00596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428221/
https://www.ncbi.nlm.nih.gov/pubmed/37504578
http://dx.doi.org/10.1021/acs.jcim.3c00596

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