MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4

BACKGROUND: Endothelial dysfunction and deregulated microRNAs (miRNAs) participate in the development of sepsis and are associated with septic organ failure and death. Here, we explored the role of miR-15b-5p on inflammatory pathways in lipopolysaccharide (LPS)-treated human endothelial cells, HUVEC...

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Detalles Bibliográficos
Autores principales: Martino, Elisa, D’Onofrio, Nunzia, Balestrieri, Anna, Mele, Luigi, Sardu, Celestino, Marfella, Raffaele, Campanile, Giuseppe, Balestrieri, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428548/
https://www.ncbi.nlm.nih.gov/pubmed/37587410
http://dx.doi.org/10.1186/s11658-023-00482-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428548/
https://www.ncbi.nlm.nih.gov/pubmed/37587410
http://dx.doi.org/10.1186/s11658-023-00482-5

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