AI-powered discovery of a novel p53-Y220C reactivator

INTRODUCTION: The p53-Y220C mutation is one of the most common mutations that play a major role in cancer progression. METHODS: In this study, we applied artificial intelligence (AI)-powered virtual screening to identify small-molecule compounds that specifically restore the wild-type p53 conformati...

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Detalles Bibliográficos
Autores principales: Zhou, Shan, Chai, Dafei, Wang, Xu, Neeli, Praveen, Yu, Xinfang, Davtyan, Aram, Young, Ken, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430779/
https://www.ncbi.nlm.nih.gov/pubmed/37593097
http://dx.doi.org/10.3389/fonc.2023.1229696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430779/
https://www.ncbi.nlm.nih.gov/pubmed/37593097
http://dx.doi.org/10.3389/fonc.2023.1229696

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