Cargando…

AI-powered discovery of a novel p53-Y220C reactivator

INTRODUCTION: The p53-Y220C mutation is one of the most common mutations that play a major role in cancer progression. METHODS: In this study, we applied artificial intelligence (AI)-powered virtual screening to identify small-molecule compounds that specifically restore the wild-type p53 conformati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Shan, Chai, Dafei, Wang, Xu, Neeli, Praveen, Yu, Xinfang, Davtyan, Aram, Young, Ken, Li, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430779/ https://www.ncbi.nlm.nih.gov/pubmed/37593097 http://dx.doi.org/10.3389/fonc.2023.1229696

Ejemplares similares

Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C
por: Stephenson Clarke, Joseph R., et al.
Publicado: (2022)

Comparison of DNA vaccines with AS03 as an adjuvant and an mRNA vaccine against SARS-CoV-2
por: Neeli, Praveen, et al.
Publicado: (2023)

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines
por: Baud, Matthias G.J., et al.
Publicado: (2018)

C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response
por: Wang, Qiping, et al.
Publicado: (2022)

Medical Imaging Biomarker Discovery and Integration Towards AI-Based Personalized Radiotherapy
por: Pang, Yaru, et al.
Publicado: (2022)

Installing a 220 MVA power transformer
por: Ordan, Julien Marius, et al.
Publicado: (2018)

Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile
por: Brown, Kate, et al.
Publicado: (2023)

Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors
por: Meller, Artur, et al.
Publicado: (2023)

Discovery of a cryptic pocket in the AI-predicted structure of PPM1D phosphatase explains the binding site and potency of its allosteric inhibitors
por: Meller, Artur, et al.
Publicado: (2023)

Load of electronics power supplies on the 220 V mains
por: Hubbeling, L
Publicado: (1979)

CompTIA A+: exams A+ essentials (220-601), 220-602, 220-603, 220-604
por: Brooks, Charles J, et al.
Publicado: (2008)

AI-based language models powering drug discovery and development
por: Liu, Zhichao, et al.
Publicado: (2021)

HMGB1/GPC3 dual targeting vaccine induces dendritic cells-mediated CD8(+)T cell immune response and elicits potential therapeutic effect in hepatocellular carcinoma
por: Shi, Xiaoqing, et al.
Publicado: (2023)

p53 Antibodies as a Diagnostic Marker for Cancer: A Meta-Analysis
por: Sobhani, Navid, et al.
Publicado: (2021)

Therapeutic cancer vaccines: From biological mechanisms and engineering to ongoing clinical trials
por: Sobhani, Navid, et al.
Publicado: (2022)

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm
por: Bauer, Matthias R., et al.
Publicado: (2020)

PRIMA-1 inhibits Y220C p53 amyloid aggregation and synergizes with cisplatin in hepatocellular carcinoma
por: Paz, Mariana M., et al.
Publicado: (2023)

CompTIA A+ 220-901 and 220-902
por: Prowse, David L
Publicado: (2016)

CompTIA A+ 220-801 and 220-802
por: Prowse, David L
Publicado: (2013)

CompTIA A+: 220-701 and 220-702
por: Prowse, David L
Publicado: (2011)

CHAIMELEON Project: Creation of a Pan-European Repository of Health Imaging Data for the Development of AI-Powered Cancer Management Tools
por: Bonmatí, Luis Martí, et al.
Publicado: (2022)

CompTIA A+ practice questions: essentials, exams 220-602, 220-603, 220-604
por: Brooks, Charles J
Publicado: (2008)

Caffeic acid phenethyl ester (CAPE) confers wild type p53 function in p53(Y220C) mutant: bioinformatics and experimental evidence
por: Radhakrishnan, Navaneethan, et al.
Publicado: (2021)

Measurement of the pp analyzing power in the vicinity of 2.20 GeV
por: Ball, J, et al.
Publicado: (1999)

Harnessing Fluorine–Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs
por: Bauer, Matthias R., et al.
Publicado: (2016)

Expanding anti-CD38 immunotherapy for lymphoid malignancies
por: Wang, Xu, et al.
Publicado: (2022)

Mutant p53 as a Regulator and Target of Autophagy
por: Shi, Yong, et al.
Publicado: (2021)

Wild type p53 function in p53(Y220C) mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence
por: Sundar, Durai, et al.
Publicado: (2019)

Wrapping Effects within a Proposed Function-Rescue Strategy for the Y220C Oncogenic Mutation of Protein p53
por: Accordino, Sebastián R., et al.
Publicado: (2013)

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C
por: Bauer, Matthias R, et al.
Publicado: (2019)

A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
por: Guiley, Keelan Z., et al.
Publicado: (2023)

CompTIA A+ 220-901 and 220-902 cert guide
por: Soper, Mark Edward
Publicado: (2017)

CompTIA A+ 220-901 and 220-902: cert guide
por: Soper, Mark Edward
Publicado: (2017)

CompTIA A+ 220-701 and 220-702 cert guide
por: Soper, Mark Edward, et al.
Publicado: (2011)

CompTIA A+ 220-701 and 220-702 practice questions
por: Regan, Patrick E
Publicado: (2011)

CompTIA A+ quick reference (220-701, 220-702)
por: Conry, Ben
Publicado: (2010)

Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas
por: Chiang, Ming-Fu, et al.
Publicado: (2013)

DEC VT220
Publicado: (1983)

CompTIA A+ 220-801 and 220-802 authorized cert guide
por: Soper, Mark Edward, et al.
Publicado: (2013)

The AI for Scientific Discovery Network(+)
por: Kanza, Samantha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vtm187tl14301gacu1a22ia2o1