Cargando…

Integrated single cell and bulk sequencing analysis identifies tumor reactive CXCR6(+) CD8 T cells as a predictor of immune infiltration and immunotherapy outcomes in hepatocellular carcinoma

BACKGROUND: Various immune cell types in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) have been identified as important parameters associated with prognosis and responsiveness to immunotherapy. However, how various factors influence immune cell infiltration remains incompletely...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiaogang, Gao, Zheng, Chen, Jiafeng, Feng, Shanru, Luo, Xuanming, Shi, Yinghong, Tang, Zheng, Liu, Weiren, Zhang, Xin, Huang, Ao, Gao, Qiang, Ke, Aiwu, Zhou, Jian, Fan, Jia, Fu, Xiutao, Ding, Zhenbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430781/ https://www.ncbi.nlm.nih.gov/pubmed/37593098 http://dx.doi.org/10.3389/fonc.2023.1099385

Ejemplares similares

SQSTM1/p62 in intrahepatic cholangiocarcinoma promotes tumor progression via epithelial–mesenchymal transition and mitochondrial function maintenance
por: Chen, Jiafeng, et al.
Publicado: (2022)

Comprehensive analysis of complement-associated molecular features in hepatocellular carcinoma: Complement-associated molecular features in hepatocellular carcinoma
por: Huang, Run, et al.
Publicado: (2022)

Laser-Induced Combinatorial Chemotherapeutic, Chemodynamic, and Photothermal Therapy for Hepatocellular Carcinoma Based on Oxaliplatin-Loaded Metal–Organic Frameworks
por: Huang, Run, et al.
Publicado: (2023)

miR-20a-5p/TGFBR2 Axis Affects Pro-inflammatory Macrophages and Aggravates Liver Fibrosis
por: Fu, Xiutao, et al.
Publicado: (2020)

Estrogen-related genes influence immune cell infiltration and immunotherapy response in Hepatocellular Carcinoma
por: Gao, Biao, et al.
Publicado: (2023)

CXCR4 Expressed by Tumor-Infiltrating B Cells in Gastric Cancer Related to Survival in the Tumor Microenvironment: An Analysis Combining Single-Cell RNA Sequencing with Bulk RNA Sequencing
por: Su, Chen, et al.
Publicado: (2023)

Effect of CXCR5-Positive Cell Infiltration on the Immune Contexture and Patient Prognosis in Head and Neck Squamous Cell Carcinoma
por: Chen, Jun, et al.
Publicado: (2020)

Editorial: Development and Potential Mechanisms of Low Molecular Weight Drugs for Cancer Immunotherapy
por: Gao, Yanfeng, et al.
Publicado: (2022)

Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing
por: Zhang, Chuan-bao, et al.
Publicado: (2023)

Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy
por: Zhao, Zi-Yue, et al.
Publicado: (2022)

CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis
por: Ye, Linsen, et al.
Publicado: (2019)

Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display
por: Wickström, Stina L., et al.
Publicado: (2019)

Immune Cell Infiltration Landscape of Ovarian Cancer to Identify Prognosis and Immunotherapy-Related Genes to Aid Immunotherapy
por: Li, Xiushen, et al.
Publicado: (2021)

Integrating bulk and single‐cell RNA sequencing reveals cellular heterogeneity and immune infiltration in hepatocellular carcinoma
por: Wang, Tingjie, et al.
Publicado: (2022)

Increased CXCR3 Expression of Infiltrating Plasma Cells in Hunner Type Interstitial Cystitis
por: Akiyama, Yoshiyuki, et al.
Publicado: (2016)

Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model
por: Tian, Mengxin, et al.
Publicado: (2020)

CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma
por: Li, Li, et al.
Publicado: (2015)

Analysis of single‐cell RNAseq identifies transitional states of T cells associated with hepatocellular carcinoma
por: Yang, Yanying, et al.
Publicado: (2020)

RNAi targeting CXCR4 inhibits proliferation and invasion of esophageal carcinoma cells
por: Wang, Tao, et al.
Publicado: (2013)

Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain
por: Chia, Kelda, et al.
Publicado: (2018)

High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy
por: Walther, Fabio, et al.
Publicado: (2022)

A novel myeloid cell marker genes related signature can indicate immune infiltration and predict prognosis of hepatocellular carcinoma: Integrated analysis of bulk and single-cell RNA sequencing
por: Zheng, Su-Su, et al.
Publicado: (2023)

Development and Validation of CXCR4 Nomogram-Based Immune Infiltration/Tumor Inflammation in Primary Glioblastoma
por: Jiang, Guannan, et al.
Publicado: (2023)

CXCR3: Here to stay to enhance cancer immunotherapy?
por: Rogava, Meri, et al.
Publicado: (2019)

CXCR2 inhibition enables NASH-HCC immunotherapy
por: Leslie, Jack, et al.
Publicado: (2022)

An integrated bioinformatic analysis of bulk and single-cell sequencing clarifies immune microenvironment and metabolic profiles of lung adenocarcinoma to predict immunotherapy efficacy
por: Li, Mengling, et al.
Publicado: (2023)

Role of bulk nanobubbles in removing organic pollutants in wastewater treatment
por: Wu, Jiajia, et al.
Publicado: (2021)

Changes of Myogenic Reactive Oxygen Species and Interleukin-6 in Contracting Skeletal Muscle Cells
por: Pan, Hongying, et al.
Publicado: (2012)

CXCR4 is a Novel Biomarker Correlated With Malignant Transformation and Immune Infiltrates in Gastric Precancerous Lesions
por: Jiang, Xiaotao, et al.
Publicado: (2021)

An Optogenetic Controllable T Cell System for Hepatocellular Carcinoma Immunotherapy
por: Zhao, Bixing, et al.
Publicado: (2019)

Bulk and single-cell characterisation of the immune heterogeneity of atherosclerosis identifies novel targets for immunotherapy
por: Xiong, Jie, et al.
Publicado: (2023)

Correlation of CXCR4/CXCR7 signaling pathway with pre-eclampsia
por: Zheng, Zhi, et al.
Publicado: (2018)

Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes
por: Diana, Julien, et al.
Publicado: (2014)

The Role of SDF-1α-CXCR4/CXCR7 in Migration of Human Periodontal Ligament Stem Cells
por: Xu, Jialei, et al.
Publicado: (2023)

Identification of the Immune Cell Infiltration Landscape in Hepatocellular Carcinoma to Predict Prognosis and Guide Immunotherapy
por: Yang, Shiyan, et al.
Publicado: (2021)

Unveiling the Role of Tumor-Infiltrating T Cells and Immunotherapy in Hepatocellular Carcinoma: A Comprehensive Review
por: Chen, Xiaokun, et al.
Publicado: (2023)

Anti-CXCR4 Antibody Combined With Activated and Expanded Natural Killer Cells for Sarcoma Immunotherapy
por: Vela, Maria, et al.
Publicado: (2019)

SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma
por: Feng, Huayi, et al.
Publicado: (2022)

Retraction Note: RNAi targeting CXCR4 inhibits proliferation and invasion of esophageal carcinoma cells
por: Wang, Tao, et al.
Publicado: (2019)

Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis
por: Hernandez, Lorena, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_irj3pnjeihm1pc970j6q44k1tc