Antinociceptive properties of losmapimod in two acute pain models in rats: behavioural analysis, immunohistochemistry, dose response, and comparison with usual analgesic drugs()

BACKGROUND: The p38 protein is a ubiquitous mitogen-activated protein kinase involved in the proinflammatory signalling pathway and in the pain response after various noxious stimuli. Many p38 inhibitors have been developed and shown to provide effective analgesia in animal models. They are, however...

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Detalles Bibliográficos
Autores principales: Soued, Mickaël, Hamdi, Leila, Ben Rehouma, Mouna, Mazoit, Jean-Xavier, Benhamou, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430813/
https://www.ncbi.nlm.nih.gov/pubmed/37588580
http://dx.doi.org/10.1016/j.bjao.2022.100029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430813/
https://www.ncbi.nlm.nih.gov/pubmed/37588580
http://dx.doi.org/10.1016/j.bjao.2022.100029

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