Physiologically‐based pharmacokinetic pharmacodynamic parent‐metabolite model of edoxaban to predict drug–drug‐disease interactions: M4 contribution

This study aimed to develop a physiologically‐based pharmacokinetic pharmacodynamic (PBPK/PD) parent‐metabolite model of edoxaban, an oral anticoagulant with a narrow therapeutic index, and to predict pharmacokinetic (PK)/PD profiles and potential drug–drug‐disease interactions (DDDIs) in patients w...

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Detalles Bibliográficos
Autores principales: Xu, Ruijuan, Liu, Wenyuan, Ge, Weihong, He, Hua, Jiang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431043/
https://www.ncbi.nlm.nih.gov/pubmed/37101392
http://dx.doi.org/10.1002/psp4.12977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431043/
https://www.ncbi.nlm.nih.gov/pubmed/37101392
http://dx.doi.org/10.1002/psp4.12977

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