Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4, P‐gp, and CYP2D6 drug–drug–gene interaction network

The antiarrhythmic agent quinidine is a potent inhibitor of cytochrome P450 (CYP) 2D6 and P‐glycoprotein (P‐gp) and is therefore recommended for use in clinical drug–drug interaction (DDI) studies. However, as quinidine is also a substrate of CYP3A4 and P‐gp, it is susceptible to DDIs involving thes...

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Detalles Bibliográficos
Autores principales: Feick, Denise, Rüdesheim, Simeon, Marok, Fatima Zahra, Selzer, Dominik, Loer, Helena Leonie Hanae, Teutonico, Donato, Frechen, Sebastian, van der Lee, Maaike, Moes, Dirk Jan A. R., Swen, Jesse J., Schwab, Matthias, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431052/
https://www.ncbi.nlm.nih.gov/pubmed/37165978
http://dx.doi.org/10.1002/psp4.12981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431052/
https://www.ncbi.nlm.nih.gov/pubmed/37165978
http://dx.doi.org/10.1002/psp4.12981

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