Using machine learning surrogate modeling for faster QSP VP cohort generation

Virtual patients (VPs) are widely used within quantitative systems pharmacology (QSP) modeling to explore the impact of variability and uncertainty on clinical responses. In one method of generating VPs, parameters are sampled randomly from a distribution, and possible VPs are accepted or rejected b...

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Detalles Bibliográficos
Autores principales: Myers, Renée C., Augustin, Florian, Huard, Jérémy, Friedrich, Christina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431055/
https://www.ncbi.nlm.nih.gov/pubmed/37328956
http://dx.doi.org/10.1002/psp4.12999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431055/
https://www.ncbi.nlm.nih.gov/pubmed/37328956
http://dx.doi.org/10.1002/psp4.12999

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