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The σ(B) alternative sigma factor circuit modulates noise to generate different types of pulsing dynamics

Single-cell approaches are revealing a high degree of heterogeneity, or noise, in gene expression in isogenic bacteria. How gene circuits modulate this noise in gene expression to generate robust output dynamics is unclear. Here we use the Bacillus subtilis alternative sigma factor σ(B) as a model s...

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Detalles Bibliográficos
Autores principales: Loman, Torkel E., Locke, James C. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431680/
https://www.ncbi.nlm.nih.gov/pubmed/37540712
http://dx.doi.org/10.1371/journal.pcbi.1011265