α-Synuclein liquid condensates fuel fibrillar α-synuclein growth

α-Synuclein (α-Syn) aggregation into fibrils with prion-like features is intimately associated with Lewy pathology and various synucleinopathies. Emerging studies suggest that α-Syn could form liquid condensates through phase separation. The role of these condensates in aggregation and disease remai...

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Detalles Bibliográficos
Autores principales: Piroska, Leonard, Fenyi, Alexis, Thomas, Scott, Plamont, Marie-Aude, Redeker, Virginie, Melki, Ronald, Gueroui, Zoher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431715/
https://www.ncbi.nlm.nih.gov/pubmed/37585526
http://dx.doi.org/10.1126/sciadv.adg5663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431715/
https://www.ncbi.nlm.nih.gov/pubmed/37585526
http://dx.doi.org/10.1126/sciadv.adg5663

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