Longevity factor klotho enhances cognition in aged nonhuman primates

Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form o...

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Detalles Bibliográficos
Autores principales: Castner, Stacy A., Gupta, Shweta, Wang, Dan, Moreno, Arturo J., Park, Cana, Chen, Chen, Poon, Yan, Groen, Aaron, Greenberg, Kenneth, David, Nathaniel, Boone, Tom, Baxter, Mark G., Williams, Graham V., Dubal, Dena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432271/
https://www.ncbi.nlm.nih.gov/pubmed/37400721
http://dx.doi.org/10.1038/s43587-023-00441-x
Descripción
Sumario:Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans.

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