Longevity factor klotho enhances cognition in aged nonhuman primates

Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form o...

Descripción completa

Detalles Bibliográficos
Autores principales: Castner, Stacy A., Gupta, Shweta, Wang, Dan, Moreno, Arturo J., Park, Cana, Chen, Chen, Poon, Yan, Groen, Aaron, Greenberg, Kenneth, David, Nathaniel, Boone, Tom, Baxter, Mark G., Williams, Graham V., Dubal, Dena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432271/
https://www.ncbi.nlm.nih.gov/pubmed/37400721
http://dx.doi.org/10.1038/s43587-023-00441-x
_version_ 1785091364258578432
author Castner, Stacy A.
Gupta, Shweta
Wang, Dan
Moreno, Arturo J.
Park, Cana
Chen, Chen
Poon, Yan
Groen, Aaron
Greenberg, Kenneth
David, Nathaniel
Boone, Tom
Baxter, Mark G.
Williams, Graham V.
Dubal, Dena B.
author_facet Castner, Stacy A.
Gupta, Shweta
Wang, Dan
Moreno, Arturo J.
Park, Cana
Chen, Chen
Poon, Yan
Groen, Aaron
Greenberg, Kenneth
David, Nathaniel
Boone, Tom
Baxter, Mark G.
Williams, Graham V.
Dubal, Dena B.
author_sort Castner, Stacy A.
collection PubMed
description Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans.
format Online
Article
Text
id pubmed-10432271
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group US
record_format MEDLINE/PubMed
spelling pubmed-104322712023-08-18 Longevity factor klotho enhances cognition in aged nonhuman primates Castner, Stacy A. Gupta, Shweta Wang, Dan Moreno, Arturo J. Park, Cana Chen, Chen Poon, Yan Groen, Aaron Greenberg, Kenneth David, Nathaniel Boone, Tom Baxter, Mark G. Williams, Graham V. Dubal, Dena B. Nat Aging Brief Communication Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans. Nature Publishing Group US 2023-07-03 2023 /pmc/articles/PMC10432271/ /pubmed/37400721 http://dx.doi.org/10.1038/s43587-023-00441-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Castner, Stacy A.
Gupta, Shweta
Wang, Dan
Moreno, Arturo J.
Park, Cana
Chen, Chen
Poon, Yan
Groen, Aaron
Greenberg, Kenneth
David, Nathaniel
Boone, Tom
Baxter, Mark G.
Williams, Graham V.
Dubal, Dena B.
Longevity factor klotho enhances cognition in aged nonhuman primates
title Longevity factor klotho enhances cognition in aged nonhuman primates
title_full Longevity factor klotho enhances cognition in aged nonhuman primates
title_fullStr Longevity factor klotho enhances cognition in aged nonhuman primates
title_full_unstemmed Longevity factor klotho enhances cognition in aged nonhuman primates
title_short Longevity factor klotho enhances cognition in aged nonhuman primates
title_sort longevity factor klotho enhances cognition in aged nonhuman primates
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432271/
https://www.ncbi.nlm.nih.gov/pubmed/37400721
http://dx.doi.org/10.1038/s43587-023-00441-x
work_keys_str_mv AT castnerstacya longevityfactorklothoenhancescognitioninagednonhumanprimates
AT guptashweta longevityfactorklothoenhancescognitioninagednonhumanprimates
AT wangdan longevityfactorklothoenhancescognitioninagednonhumanprimates
AT morenoarturoj longevityfactorklothoenhancescognitioninagednonhumanprimates
AT parkcana longevityfactorklothoenhancescognitioninagednonhumanprimates
AT chenchen longevityfactorklothoenhancescognitioninagednonhumanprimates
AT poonyan longevityfactorklothoenhancescognitioninagednonhumanprimates
AT groenaaron longevityfactorklothoenhancescognitioninagednonhumanprimates
AT greenbergkenneth longevityfactorklothoenhancescognitioninagednonhumanprimates
AT davidnathaniel longevityfactorklothoenhancescognitioninagednonhumanprimates
AT boonetom longevityfactorklothoenhancescognitioninagednonhumanprimates
AT baxtermarkg longevityfactorklothoenhancescognitioninagednonhumanprimates
AT williamsgrahamv longevityfactorklothoenhancescognitioninagednonhumanprimates
AT dubaldenab longevityfactorklothoenhancescognitioninagednonhumanprimates

Ejemplares similares