Trimethoprim resistance in surface and wastewater is mediated by contrasting variants of the dfrB gene

Trimethoprim (TMP) is a low-cost, widely prescribed antibiotic. Its effectiveness is increasingly challenged by the spread of genes coding for TMP-resistant dihydrofolate reductases: dfrA, and the lesser-known, evolutionarily unrelated dfrB. Despite recent reports of novel variants conferring high l...

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Detalles Bibliográficos
Autores principales: Kneis, David, Lemay-St-Denis, Claudèle, Cellier-Goetghebeur, Stella, Elena, Alan X., Berendonk, Thomas U., Pelletier, Joelle N., Heß, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432401/
https://www.ncbi.nlm.nih.gov/pubmed/37369703
http://dx.doi.org/10.1038/s41396-023-01460-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432401/
https://www.ncbi.nlm.nih.gov/pubmed/37369703
http://dx.doi.org/10.1038/s41396-023-01460-7

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