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Trimethoprim resistance in surface and wastewater is mediated by contrasting variants of the dfrB gene

Trimethoprim (TMP) is a low-cost, widely prescribed antibiotic. Its effectiveness is increasingly challenged by the spread of genes coding for TMP-resistant dihydrofolate reductases: dfrA, and the lesser-known, evolutionarily unrelated dfrB. Despite recent reports of novel variants conferring high l...

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Detalles Bibliográficos
Autores principales:	Kneis, David, Lemay-St-Denis, Claudèle, Cellier-Goetghebeur, Stella, Elena, Alan X., Berendonk, Thomas U., Pelletier, Joelle N., Heß, Stefanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432401/ https://www.ncbi.nlm.nih.gov/pubmed/37369703 http://dx.doi.org/10.1038/s41396-023-01460-7

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