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Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model

Drug-induced liver injury induced by already approved substances is a major threat to human patients, potentially resulting in drug withdrawal and substantial loss of financial resources in the pharmaceutical industry. Trovafloxacin, a broad-spectrum fluoroquinolone, was found to have unexpected sid...

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Detalles Bibliográficos
Autores principales: Kaden, Tim, Graf, Katja, Rennert, Knut, Li, Ruoya, Mosig, Alexander S., Raasch, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432496/
https://www.ncbi.nlm.nih.gov/pubmed/37587168
http://dx.doi.org/10.1038/s41598-023-40004-z