Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells

The cytokine interleukin-23 (IL-23) is involved in the pathogenesis of inflammatory and autoimmune conditions including inflammatory bowel disease (IBD). IL23R is enriched in intestinal Tregs, yet whether IL-23 modulates intestinal Tregs remains unknown. Here, investigating IL-23R signaling in Tregs...

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Detalles Bibliográficos
Autores principales: Jacobse, Justin, Brown, Rachel E., Li, Jing, Pilat, Jennifer M., Pham, Ly, Short, Sarah P., Peek, Christopher T., Rolong, Andrea, Washington, M. Kay, Martinez-Barricarte, Ruben, Byndloss, Mariana X., Shelton, Catherine, Markle, Janet G., Latour, Yvonne L., Allaman, Margaret M., Cassat, James E., Wilson, Keith T., Choksi, Yash A., Williams, Christopher S., Lau, Ken S., Flynn, Charles R., Casanova, Jean-Laurent, Rings, Edmond H.H.M., Samsom, Janneke N., Goettel, Jeremy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432575/
https://www.ncbi.nlm.nih.gov/pubmed/36807140
http://dx.doi.org/10.1016/j.celrep.2023.112128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432575/
https://www.ncbi.nlm.nih.gov/pubmed/36807140
http://dx.doi.org/10.1016/j.celrep.2023.112128

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