TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

BACKGROUND: Adoptive cell therapy (ACT) has shown promising results for the treatment of cancer and viral infections. Successful ACT relies on ex vivo expansion of large numbers of desired T-cells with strong cytotoxic capacity and in vivo persistence, which constitutes the greatest challenge to cur...

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Detalles Bibliográficos
Autores principales: Tvingsholm, Siri Amanda, Frej, Marcus Svensson, Rafa, Vibeke Mindahl, Hansen, Ulla Kring, Ormhøj, Maria, Tyron, Alexander, Jensen, Agnete W P, Kadivar, Mohammad, Bentzen, Amalie Kai, Munk, Kamilla K, Aasbjerg, Gitte N, Ternander, Jeppe S H, Heeke, Christina, Tamhane, Tripti, Schmess, Christian, Funt, Samuel A., Kjeldsen, Julie Westerlin, Kverneland, Anders Handrup, Met, Özcan, Draghi, Arianna, Jakobsen, Søren Nyboe, Donia, Marco, Marie Svane, Inge, Hadrup, Sine Reker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432666/
https://www.ncbi.nlm.nih.gov/pubmed/37586765
http://dx.doi.org/10.1136/jitc-2023-006847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432666/
https://www.ncbi.nlm.nih.gov/pubmed/37586765
http://dx.doi.org/10.1136/jitc-2023-006847

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