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The germline HLA-A02B62 supertype is associated with a PD-L1-positive tumour immune microenvironment and poor prognosis in stage I lung cancer

BACKGROUND: Germline HLA class I molecule supertypes are shown to correlate with response to anti-PD-1 therapy. Here, we investigate the significance of germline HLA-A and HLA-B supertypes in tumour microenvironment of non-small-cell lung cancer. METHODS: Totally 278 NSCLC patients were collected re...

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Detalles Bibliográficos
Autores principales: Lin, Ruijiang, Chen, Xiaohua, Su, Fei, Wang, Hongbin, Han, Biao, Chen, Yanhui, Zhang, Cuixiang, Ma, Minjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432705/
https://www.ncbi.nlm.nih.gov/pubmed/37600368
http://dx.doi.org/10.1016/j.heliyon.2023.e18948