High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs

CD8(+) T cell-mediated recognition of peptide-major histocompatibility complex class I (pMHCI) molecules involves cooperative binding of the T cell receptor (TCR), which confers antigen specificity, and the CD8 coreceptor, which stabilizes the TCR/pMHCI complex. Earlier work has shown that the sensi...

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Detalles Bibliográficos
Autores principales: Knezevic, Lea, Wachsmann, Tassilo L.A., Francis, Ore, Dockree, Tamsin, Bridgeman, John S., Wouters, Anne, de Wet, Ben, Cole, David K., Clement, Mathew, McLaren, James E., Gostick, Emma, Ladell, Kristin, Llewellyn-Lacey, Sian, Price, David A., van den Berg, Hugo A., Tabi, Zsuzsanna, Sessions, Richard B., Heemskerk, Mirjam H.M., Wooldridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432799/
https://www.ncbi.nlm.nih.gov/pubmed/37390984
http://dx.doi.org/10.1016/j.jbc.2023.104981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432799/
https://www.ncbi.nlm.nih.gov/pubmed/37390984
http://dx.doi.org/10.1016/j.jbc.2023.104981

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