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Modeling Parkinson’s disease in LRRK2 rodents

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson’s disease (PD). Sporadic PD and LRRK2 PD share main clinical and neuropathological features, namely hypokinesia, degeneration of nigro-striatal dopamine neurons and α-synuclein agg...

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Detalles Bibliográficos
Autores principales: Domenicale, Chiara, Magnabosco, Stefano, Morari, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432857/
https://www.ncbi.nlm.nih.gov/pubmed/37601008
http://dx.doi.org/10.1042/NS20220040