A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model

Growth Differentiation Factor‐15 (GDF15) is a circulating polypeptide linked to cellular stress and metabolic adaptation. GDF15's half‐life is ~3 h and activates the glial cell line‐derived neurotrophic factor family receptor alpha‐like (GFRAL) receptor expressed in the area postrema. To charac...

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Detalles Bibliográficos
Autores principales: Zheng, Songmao, Polidori, David, Wang, Yuanping, Geist, Brian, Lin‐Schmidt, Xiefan, Furman, Jennifer L., Nelson, Serena, Nawrocki, Andrea R., Hinke, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432867/
https://www.ncbi.nlm.nih.gov/pubmed/37154518
http://dx.doi.org/10.1111/cts.13543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432867/
https://www.ncbi.nlm.nih.gov/pubmed/37154518
http://dx.doi.org/10.1111/cts.13543

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