Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution

The risk of severe adverse events related to thiopurine therapy can be reduced by personalizing dosing based on TPMT and NUDT15 genetic polymorphisms. However, the optimal genetic testing platform has not yet been established. In this study, we report on the TPMT and NUDT15 genotypes and phenotypes...

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Detalles Bibliográficos
Autores principales: Cook, Kelsey J., Grusauskas, Victoria, Gloe, Lucy, Duong, Benjamin Q., Gresh, Renee C., Kolb, E. Anders, Bansal, Manisha, Bechtel, Allison S., Nagasubramanian, Ramamoorthy, Kirwin, Susan M., Blake, Kathryn V., Seligson, Nathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432880/
https://www.ncbi.nlm.nih.gov/pubmed/37415296
http://dx.doi.org/10.1111/cts.13539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432880/
https://www.ncbi.nlm.nih.gov/pubmed/37415296
http://dx.doi.org/10.1111/cts.13539

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