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Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts
OBJECTIVE: The aim of this case-control study was to investigate environmental factors, such as caffeine, folic acid, nutritional iron supplementation, multivitamin complexes, alcohol, and tobacco (second-hand smoking), which have been described as risk factors for the development of oral clefts. ME...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432903/ https://www.ncbi.nlm.nih.gov/pubmed/37567043 http://dx.doi.org/10.1016/j.clinsp.2023.100266 |
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author | de Andrade, Rodrigo Soares Oliveira, Fabrício Emanuel Soares de Martelli, Daniella Reis Barbosa de Barros, Letízia Monteiro Martelli Júnior, Hercílio |
author_facet | de Andrade, Rodrigo Soares Oliveira, Fabrício Emanuel Soares de Martelli, Daniella Reis Barbosa de Barros, Letízia Monteiro Martelli Júnior, Hercílio |
author_sort | de Andrade, Rodrigo Soares |
collection | PubMed |
description | OBJECTIVE: The aim of this case-control study was to investigate environmental factors, such as caffeine, folic acid, nutritional iron supplementation, multivitamin complexes, alcohol, and tobacco (second-hand smoking), which have been described as risk factors for the development of oral clefts. METHODS: This case-control study employed convenience sampling and included 409 mothers: 132 with children with oral clefts (cases) and 277 with children without oral clefts (controls). The age range of the children in both groups was 0 to 2 years. A questionnaire was administered to each mother to inquire about their habits and food consumption during the first trimester of pregnancy. RESULTS: Folic acid supplementation was observed in 116 (87.8%) of the case group (p < 0.001) and 271 (97.8%) of the control group. Regarding the use of ferrous sulfate, 114 (86.3%) of the case group and 271 (97.8%) of the control group reported using it. In the case group, 84 (63.6%) mothers reported being exposed to second-hand smoke, and 5 (3.7%) reported alcohol consumption (p = 0.797). In terms of caffeine consumption, 127 mothers (95.4%) in the case group consumed it (p = 0.13), while 247 (88.8%) reported consumption in the control group. CONCLUSIONS: The results suggest a direct relationship between secondhand smoke, alcohol consumption, and the lack of maternal supplementation with oral clefts. |
format | Online Article Text |
id | pubmed-10432903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-104329032023-08-18 Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts de Andrade, Rodrigo Soares Oliveira, Fabrício Emanuel Soares de Martelli, Daniella Reis Barbosa de Barros, Letízia Monteiro Martelli Júnior, Hercílio Clinics (Sao Paulo) Original Articles OBJECTIVE: The aim of this case-control study was to investigate environmental factors, such as caffeine, folic acid, nutritional iron supplementation, multivitamin complexes, alcohol, and tobacco (second-hand smoking), which have been described as risk factors for the development of oral clefts. METHODS: This case-control study employed convenience sampling and included 409 mothers: 132 with children with oral clefts (cases) and 277 with children without oral clefts (controls). The age range of the children in both groups was 0 to 2 years. A questionnaire was administered to each mother to inquire about their habits and food consumption during the first trimester of pregnancy. RESULTS: Folic acid supplementation was observed in 116 (87.8%) of the case group (p < 0.001) and 271 (97.8%) of the control group. Regarding the use of ferrous sulfate, 114 (86.3%) of the case group and 271 (97.8%) of the control group reported using it. In the case group, 84 (63.6%) mothers reported being exposed to second-hand smoke, and 5 (3.7%) reported alcohol consumption (p = 0.797). In terms of caffeine consumption, 127 mothers (95.4%) in the case group consumed it (p = 0.13), while 247 (88.8%) reported consumption in the control group. CONCLUSIONS: The results suggest a direct relationship between secondhand smoke, alcohol consumption, and the lack of maternal supplementation with oral clefts. Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo 2023-08-09 /pmc/articles/PMC10432903/ /pubmed/37567043 http://dx.doi.org/10.1016/j.clinsp.2023.100266 Text en © 2023 HCFMUSP. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Articles de Andrade, Rodrigo Soares Oliveira, Fabrício Emanuel Soares de Martelli, Daniella Reis Barbosa de Barros, Letízia Monteiro Martelli Júnior, Hercílio Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts |
title | Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts |
title_full | Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts |
title_fullStr | Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts |
title_full_unstemmed | Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts |
title_short | Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts |
title_sort | maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432903/ https://www.ncbi.nlm.nih.gov/pubmed/37567043 http://dx.doi.org/10.1016/j.clinsp.2023.100266 |
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