sut-2 loss of function mutants protect against tau-driven shortened lifespan and hyperactive pharyngeal pumping in a C. elegans model of tau toxicity

Expression of human tau in C. elegans neurons causes progressive, age-associated loss of motor coordination, selective neurodegeneration, and shortened lifespan. Loss of function (LOF) mutations in the conserved gene sut-2 protects against progressive motor uncoordination and neurodegeneration in mo...

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Detalles Bibliográficos
Autores principales: Currey, Heather N, Kraemer, Brian C., Liachko, Nicole F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
Findings Previously Not Shown
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432939/
https://www.ncbi.nlm.nih.gov/pubmed/37602280
http://dx.doi.org/10.17912/micropub.biology.000844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432939/
https://www.ncbi.nlm.nih.gov/pubmed/37602280
http://dx.doi.org/10.17912/micropub.biology.000844

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