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Stress-induced pseudokinase TRB3 augments IL1β signaling by interacting with Flightless homolog 1
Interleukin-1β is one of the most potent inducers of beta cell inflammation in the lead-up to type 1 diabetes. We have previously reported that IL1β-stimulated pancreatic islets from mice with genetic ablation of stress-induced pseudokinase TRB3(TRB3KO) show attenuated activation kinetics for the MA...
Autores principales: | Gonuguntla, Sumati, Humphrey, Rohan K., Gorantla, Akshita, Hao, Ergeng, Jhala, Ulupi S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432976/ https://www.ncbi.nlm.nih.gov/pubmed/37172723 http://dx.doi.org/10.1016/j.jbc.2023.104803 |
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