Cargando…

Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer

The cGAS/STING signaling pathway plays a pivotal role in regulating innate immunity. Emerging novel drugs aim to regulate the anti-tumor immune response by activating innate immunity. The anti-diabetic drug metformin has been reported to exhibit anti-cancer effect against various types of cancer. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Qian, Yang, Lei, Li, Chengguo, Wang, Tao, Lv, Jianbo, Liu, Weizhen, Lin, Yao, Yin, Yuping, Tao, Kaixiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432977/ https://www.ncbi.nlm.nih.gov/pubmed/37600406 http://dx.doi.org/10.1016/j.heliyon.2023.e18954

Ejemplares similares

Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells
por: Li, Chengguo, et al.
Publicado: (2021)

Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING‐dependent therapy‐induced senescence and provides “one‐two punch” opportunity with anti‐PD‐L1 therapy in colorectal cancer
por: Wang, Tao, et al.
Publicado: (2023)

cGAS/STING: novel perspectives of the classic pathway
por: Gao, Menghui, et al.
Publicado: (2020)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
por: Hong, Christy, et al.
Publicado: (2019)

The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies
por: Zheng, Weitao, et al.
Publicado: (2023)

cGAS-STING pathway in cancer biotherapy
por: Wang, Yang, et al.
Publicado: (2020)

Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction
por: Yu, Huilin, et al.
Publicado: (2022)

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
por: Zheng, Juyan, et al.
Publicado: (2020)

cGAS/STING signaling in the regulation of rheumatoid synovial aggression
por: Li, Ruiru, et al.
Publicado: (2022)

cGAS-STING pathway in oncogenesis and cancer therapeutics
por: Hoong, Brandon Yi Da, et al.
Publicado: (2020)

Attenuation of cGAS/STING activity during mitosis
por: Uhlorn, Brittany L, et al.
Publicado: (2020)

The interactions between cGAS-STING pathway and pathogens
por: Cheng, Zhangliang, et al.
Publicado: (2020)

cGAS-STING, an important pathway in cancer immunotherapy
por: Jiang, Minlin, et al.
Publicado: (2020)

The Complexity of the cGAS-STING Pathway in CNS Pathologies
por: Fryer, Amelia L., et al.
Publicado: (2021)

The role of cGAS-STING signalling in liver diseases
por: Chen, Ruihan, et al.
Publicado: (2021)

Advances in cGAS-STING Signaling Pathway and Diseases
por: Yang, Yuting, et al.
Publicado: (2022)

Mitotic inactivation of the cGAS‒MITA/STING pathways
por: Zhong, Li, et al.
Publicado: (2021)

Telomere Maintenance and the cGAS-STING Pathway in Cancer
por: Ebata, Hiroshi, et al.
Publicado: (2022)

Intercellular transmission of cGAS-STING signaling in cancer
por: Wu, Qirou, et al.
Publicado: (2023)

Role of cGAS–Sting Signaling in Alzheimer’s Disease
por: Govindarajulu, Manoj, et al.
Publicado: (2023)

The Activation of cGAS-STING in Acute Kidney Injury
por: Sun, Chuanchuan, et al.
Publicado: (2023)

Targeting the loss of cGAS/STING signaling in cancer
por: Sasaki, Nobunari, et al.
Publicado: (2023)

Significance of the cGAS-STING Pathway in Health and Disease
por: Zhou, Jinglin, et al.
Publicado: (2023)

cGAS-STING triggers inflammaging-associated neurodegeneration
por: Izquierdo, José M.
Publicado: (2023)

PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3
por: Bo, Zongyi, et al.
Publicado: (2020)

Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS
por: Webb, L. G., et al.
Publicado: (2020)

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy
por: Li, Anping, et al.
Publicado: (2019)

The cGAS-STING Defense Pathway and Its Counteraction by Viruses
por: Ma, Zhe, et al.
Publicado: (2016)

cGAS-independent STING activation in response to DNA damage
por: Unterholzner, Leonie, et al.
Publicado: (2019)

Conserved strategies for pathogen evasion of cGAS–STING immunity
por: Eaglesham, James B, et al.
Publicado: (2020)

The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance
por: Liao, Weinian, et al.
Publicado: (2020)

Activation of the cGAS–STING signaling pathway in adenomyosis patients
por: Lin, Yun, et al.
Publicado: (2021)

Activation of cGAS/STING pathway upon paramyxovirus infection
por: Iampietro, Mathieu, et al.
Publicado: (2021)

The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
por: Mohseni, Ghazal, et al.
Publicado: (2021)

The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity
por: Liu, Nanxin, et al.
Publicado: (2022)

The cGAS-STING Pathway: Novel Perspectives in Liver Diseases
por: Xu, Dongwei, et al.
Publicado: (2021)

The cGAS-STING Pathway: A Promising Immunotherapy Target
por: Ou, Liang, et al.
Publicado: (2021)

cGAS‒STING signaling and function in metabolism and kidney diseases
por: Bai, Juli, et al.
Publicado: (2021)

Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus
por: Wobma, Holly, et al.
Publicado: (2022)

Intervention of cGAS‒STING signaling in sterile inflammatory diseases
por: Hong, Ze, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d459utg60vn39ev1j8l5lddjf1