Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing the NAD(+)-dependent deacetylase, SIRT3, reduced oxidative stress...

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Detalles Bibliográficos
Autores principales: Garcia Castro, David R., Mazuk, Joseph R., Heine, Erin M., Simpson, Daniel, Pinches, R. Seth, Lozzi, Caroline, Hoffman, Kathryn, Morrin, Phillip, Mathis, Dylan, Lebedev, Maria V., Nissley, Elyse, Han, Kang Hoo, Farmer, Tyler, Merry, Diane E., Tong, Qiang, Pennuto, Maria, Montie, Heather L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433013/
https://www.ncbi.nlm.nih.gov/pubmed/37599829
http://dx.doi.org/10.1016/j.isci.2023.107375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433013/
https://www.ncbi.nlm.nih.gov/pubmed/37599829
http://dx.doi.org/10.1016/j.isci.2023.107375

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