Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells

Endoplasmic reticulum (ER) stress and apoptosis play significant roles in the development of neurotoxicity caused by bupivacaine (BUP). By activating sirtuin 1 (SIRT1), resveratrol (RSV) can regulate various cellular processes associated with anti-oxidative stress, anti-apoptosis and anti-inflammato...

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Detalles Bibliográficos
Autores principales: Luo, Yunpeng, Hu, Na, Zhao, Yang, Lai, Jian, Luo, Xi, Liu, Jingchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433439/
https://www.ncbi.nlm.nih.gov/pubmed/37602306
http://dx.doi.org/10.3892/etm.2023.12132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433439/
https://www.ncbi.nlm.nih.gov/pubmed/37602306
http://dx.doi.org/10.3892/etm.2023.12132

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