Cargando…

Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells

Endoplasmic reticulum (ER) stress and apoptosis play significant roles in the development of neurotoxicity caused by bupivacaine (BUP). By activating sirtuin 1 (SIRT1), resveratrol (RSV) can regulate various cellular processes associated with anti-oxidative stress, anti-apoptosis and anti-inflammato...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Yunpeng, Hu, Na, Zhao, Yang, Lai, Jian, Luo, Xi, Liu, Jingchen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433439/ https://www.ncbi.nlm.nih.gov/pubmed/37602306 http://dx.doi.org/10.3892/etm.2023.12132

Ejemplares similares

Resveratrol Suppresses Bupivacaine-Induced Spinal Neurotoxicity in Rats by Inhibiting Endoplasmic Reticulum Stress via SIRT1 Modulation
por: Luo, Yunpeng, et al.
Publicado: (2023)

Rifampicin Protects PC12 Cells from Rotenone-Induced Cytotoxicity by Activating GRP78 via PERK-eIF2α-ATF4 Pathway
por: Jing, Xiuna, et al.
Publicado: (2014)

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis
por: Dias-Teixeira, Karina Luiza, et al.
Publicado: (2017)

GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells
por: Gundu, Chayanika, et al.
Publicado: (2022)

Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice
por: Tang, Xiaole, et al.
Publicado: (2020)

Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway
por: Wu, Lili, et al.
Publicado: (2021)

Protective Effect of Resveratrol Against Corticosterone-induced Neurotoxicity in PC12 Cells
por: Zhang, Ye, et al.
Publicado: (2019)

Retracted: Resveratrol Suppresses Bupivacaine-Induced Spinal Neurotoxicity in Rats by Inhibiting Endoplasmic Reticulum Stress via SIRT1 Modulation
por: International, BioMed Research
Publicado: (2023)

PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification
por: Masuda, Masashi, et al.
Publicado: (2013)

PUM1 knockdown prevents tumor progression by activating the PERK/eIF2/ATF4 signaling pathway in pancreatic adenocarcinoma cells
por: Dai, Haisu, et al.
Publicado: (2019)

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
por: Teske, Brian F., et al.
Publicado: (2011)

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats
por: Liu, Benquan, et al.
Publicado: (2019)

Melatonin Inhibits Glucose-Induced Apoptosis in Osteoblastic Cell Line Through PERK-eIF2α-ATF4 Pathway
por: Zhou, Renyi, et al.
Publicado: (2020)

Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2α axis
por: Zhu, Xiaohua, et al.
Publicado: (2023)

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway
por: Sun, Jing, et al.
Publicado: (2021)

Analogs of imine resveratrol alleviate oxidative stress‐induced neurotoxicity in PC12 cells via activation of Nrf2
por: Zhang, Yin, et al.
Publicado: (2021)

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2
por: Saito, Atsushi, et al.
Publicado: (2011)

NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK–eIF2α–ATF4 signalling in breast cancer
por: Gupta, A, et al.
Publicado: (2016)

Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway
por: Chen, Yi-Jen, et al.
Publicado: (2013)

The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy
por: Xu, Xiaohui, et al.
Publicado: (2020)

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma
por: Kim, Sanghwa, et al.
Publicado: (2021)

Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK–eIF2α–ATF4 axis
por: Watanabe, Yuichi, et al.
Publicado: (2021)

miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4
por: He, Ling, et al.
Publicado: (2016)

Lobaplatin promotes (125)I-induced apoptosis and inhibition of proliferation in hepatocellular carcinoma by upregulating PERK-eIF2α-ATF4-CHOP pathway
por: Li, Dong, et al.
Publicado: (2019)

7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway
por: Tsai, Tsung-Chang, et al.
Publicado: (2018)

Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2α-ATF4-CHOP Signaling Pathway
por: Wang, Wanzhen, et al.
Publicado: (2023)

Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
por: Wang, Lihuai, et al.
Publicado: (2023)

Esophageal cancer stem cells reduce hypoxia-induced apoptosis by inhibiting the GRP78-perk-eIF2α-ATF4-CHOP pathway in vitro
por: Lin, Ruijiang, et al.
Publicado: (2023)

High glucose and bupivacaine-induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK-ATF4-CHOP and IRE1-TRAF2 signaling pathways
por: Liu, Yongzhe, et al.
Publicado: (2019)

Experimental study on the neurotoxic effect of β-amyloid on the cytoskeleton of PC12 cells
por: Wang, Lai, et al.
Publicado: (2018)

Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells
por: Jiang, Q, et al.
Publicado: (2014)

Fuziline alleviates isoproterenol‐induced myocardial injury by inhibiting ROS‐triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway
por: Fan, Cai‐lian, et al.
Publicado: (2019)

Doxorubicin Induces Cytotoxicity through Upregulation of pERK–Dependent ATF3
por: Park, Eun-Jung, et al.
Publicado: (2012)

Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
por: Mendes, Andreia, et al.
Publicado: (2020)

Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes
por: Ikeda, Shin-ichi, et al.
Publicado: (2022)

Ultraviolet Photolysis of Chlorpyrifos: Developmental Neurotoxicity Modeled in PC12 Cells
por: Slotkin, Theodore A., et al.
Publicado: (2009)

Endoplasmic Reticulum Stress-Activated PERK-eIF2α-ATF4 Signaling Pathway is Involved in the Ameliorative Effects of Ginseng Polysaccharides against Cisplatin-Induced Nephrotoxicity in Mice
por: Wei, Xiao-meng, et al.
Publicado: (2021)

PCV2 and PRV Coinfection Induces Endoplasmic Reticulum Stress via PERK-eIF2α-ATF4-CHOP and IRE1-XBP1-EDEM Pathways
por: Chen, Si, et al.
Publicado: (2022)

Inhibition of TRPA1 Ameliorates Periodontitis by Reducing Periodontal Ligament Cell Oxidative Stress and Apoptosis via PERK/eIF2α/ATF-4/CHOP Signal Pathway
por: Liu, Qian, et al.
Publicado: (2022)

Oleanolic Acid Mitigates 6-Hydroxydopamine Neurotoxicity by Attenuating Intracellular ROS in PC12 Cells and Striatal Microglial Activation in Rat Brains
por: Msibi, Zama N. P., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9m240a1qgipbg7tdujf9rmb5mr