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Slow Dissociation from the PARP1–HPF1 Complex Drives Inhibitor Potency
[Image: see text] PARP1, upon binding to damaged DNA, is activated to perform poly ADP-ribosylation (PARylation) on itself and other proteins, which leads to relaxation of chromatin and recruitment of DNA repair factors. HPF1 was recently discovered as a protein cofactor of PARP1 that directs prefer...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433523/ https://www.ncbi.nlm.nih.gov/pubmed/37531469 http://dx.doi.org/10.1021/acs.biochem.3c00243 |