Targeting sphingolipid metabolism with the sphingosine kinase inhibitor SKI-II overcomes hypoxia-induced chemotherapy resistance in glioblastoma cells: effects on cell death, self-renewal, and invasion

BACKGROUND: Glioblastoma patients commonly develop resistance to temozolomide chemotherapy. Hypoxia, which supports chemotherapy resistance, favors the expansion of glioblastoma stem cells (GSC), contributing to tumor relapse. Because of a deregulated sphingolipid metabolism, glioblastoma tissues co...

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Detalles Bibliográficos
Autores principales: Sousa, Nadia, Geiß, Carsten, Bindila, Laura, Lieberwirth, Ingo, Kim, Ella, Régnier-Vigouroux, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433583/
https://www.ncbi.nlm.nih.gov/pubmed/37587449
http://dx.doi.org/10.1186/s12885-023-11271-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433583/
https://www.ncbi.nlm.nih.gov/pubmed/37587449
http://dx.doi.org/10.1186/s12885-023-11271-w

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