Endogenous PTEN acts as the key determinant for mTOR inhibitor sensitivity by inducing the stress-sensitized PTEN-mediated death axis in KSHV-associated malignant cells

As a part of viral cancer evolution, KSHV-infected human endothelial cells exert a unique transcriptional program via upregulated mTORC1 signaling. This event makes them sensitive to mTOR inhibitors. Master transcriptional regulator PTEN acts as the prime regulator of mTOR and determining factor for...

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Detalles Bibliográficos
Autores principales: Das, Piyanki, Pal, Sonali, Das, Nilanjana, Chakraborty, Koushik, Chatterjee, Koustav, Mal, Sudipa, Choudhuri, Tathagata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433768/
https://www.ncbi.nlm.nih.gov/pubmed/37602330
http://dx.doi.org/10.3389/fmolb.2023.1062462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433768/
https://www.ncbi.nlm.nih.gov/pubmed/37602330
http://dx.doi.org/10.3389/fmolb.2023.1062462

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